Semisynthetic .BETA.-lactam antibiotics. II Synthesis and antibacterial activity of 7.BETA.-(2-(acylamino)-2-(2-aminothiazol-4-yl)acetamido)cephalosporins.
نویسندگان
چکیده
منابع مشابه
Studies on monocyclic beta-lactam antibiotics. II. Synthesis and antibacterial activity of 3-acylamino-2-azetidinone-1-oxysulfonic acids.
The synthesis and in vitro antibacterial and beta-lactamase inhibitory activity of the 2-azetidinone-1-oxysulfonic acids having a substituent at C-4 position of the beta-lactam ring are described. The influence of C-4 substituents on the antibacterial activity was examined for the compounds having alpha-ureidoacetyl or alpha-oxyiminoacetyl group as acyl side chain at C-3 position. The antibacte...
متن کاملSTUDIES ON CEPHALOSPORIN ANTIBIOTICS IV. SYNTHESIS, ANTIBACTERIAL ACTIVITY AND ORAL ABSORPTION OF NEW 3-(2-SUBSTITUTED-VINYLTHIO)-7j5- [(Z)-2-(2-AMINOTHIAZOL-4-YL)-2-
A series of new 7j5-[(Z)-2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]cephalosporins (1) having various substituted-vinylthio groups at the C-3 position of the cephem nucleus was synthesized and evaluated for antibacterial activity and oral absorption in rats in comparison with cefixime. Of these, the cephalosporins (la and lc) with a lower alkoxycarbonylvinylthio group (Z-form) at ...
متن کاملSynthesis and antibacterial activity of 7-[2-(2-aminooxazol-4-yl)-(Z)-2-alkoxyiminoacetamido]-cephalosporin antibiotics.
In a previous paper3), we reported on the synthesis and the biological activity of 3-methoxymethyl cephalosporin derivatives, one of which, cefpodoxime proxetil (Fig. 1), has been successfully developed as a prodrug for oral use. Our further elaboration for developing orally active cephalosporins has been made in the direction of chemical modification of the C-7 acyl substituent of the 3-methox...
متن کاملSTUDIES ON CEPHALOSPORIN ANTIBIOTICS III. SYNTHESIS, ANTIBACTERIAL ACTIVITY AND ORAL ABSORPTION OF NEW 3-(SUBSTITUTED-ALKYLTHIO)-7j8-[(Z)-2-(2-AMINOTHIAZOL-4-YL)- 2-(CARBOXYMETHOXYIMINO)ACETAMIDO] CEPHALOSPORINS
The synthesis, antibacterial activity and oral absorption in rats of new 7/?-[(Z)-2-(2-aminothiazol4-yl)-2-(carboxymethoxyimino)acetamido]cephalosporins (1) having various substituted-alkylthio groups at the C-3 position of the cephemnucleus are described. Of these, the cephalosporins with a cyanomethylthio group (Id) and fluoroethylthio group (lp) at the C-3 position showed a potent in vitro a...
متن کاملheterotropic effect of β-lactam antibiotics on antioxidant property of haptoglobin) 2-2(-hemoglobin complex
haptoglobin (hp) is a mammalian serum glycoprotein showing a genetic polymorphism with three types, 1-1, 2-2 and 1-2. hp appears to conserve the recycling of heme-iron by forming an essentially irreversible but non-covalent complex with hemoglobin which is released into the plasma by erythrocyte lysis. as an important consequence, haptoglobin-hemoglobin complex (hp-hb) shows considerable antiox...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1986
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.39.1236